Drug treatment of uterine fibroids
This has to be the talk about the pathogenesis of uterine fibroids. Past that its occurrence and estrogen, which includes male hormone testosterone propionate treatment, to fight; or estrogen receptor blocker tamoxifen to reduce estrogen’s role in it, but the effect of these drugs is not satisfactory . Filicori 1983 Creative GnRH-a (Gonadotropin releasing hormone agonist) therapy it. Its mechanism is linked through a series of pharmacological effects, resulting in hypogonadism (low estrogen environment similar to their drug-induced removal of ovaries), and the uterus and fibroids reduced blood flow, and finally the fibroids shrink. Significantly reduce the effect of the drug it is difficult to compare with previous drugs. However, the drug prices are high and need daily intramuscular treatment period of up to 3-6 months, limiting its widespread use. In recent years, with the rapid development of medical science, that it is also related to the occurrence and progesterone. According to this mechanism, first of all in 1993, Murphy and progesterone receptor antagonist Ru486 (mifepristone domestic drug name) for the treatment of it, and to block progesterone’s role in it, and achieved satisfactory results. According to recent literature, mifepristone and GnRH-a comparison, the reduction of its efficacy is similar, but its light and low incidence of side effects, relapse rate after treatment is lower than the latter. This medicine is tablets, daily oral 1 to, the price is low, which has allowed easy for the patient receiving the drug, easy to spread.
Clinical use of this drug that has a different degree of fibroids after treatment reduced symptoms of anemia, red blood cells, hemoglobin targets were back to normal. The drug treatment of uterine fibroids especially applies to the following two conditions: first, women with menopause, it can be reduced after treatment, some experts believe that there is the role of early menopause. On menopausal dysfunctional uterine bleeding accompanied by a drug can be said that the three had, the month after treatment stopped by the vast majority of patient, so that bleeding stopped (after the end of treatment, usually within six weeks recovery period). Second, patients with severe anemia great, so use of this drug before surgery fibroids shrink, easy-to-womb surgery to reduce bleeding, which can make surgery without blood transfusion or less blood transfusion. Department of reasons for infertility caused by uterine fibroids, the fibroids shrink after treatment, uterine fibroids can be excised as a simple technique to retain the uterus, creating conditions for the birth.
Since mifepristone for the treatment of uterine fibroids, there have been considerable portion of the surgery relieved the pain patient, but the drug must have under the guidance of experienced physicians choose to use. In clinical application must be strictly and carefully control their indications and contraindications. Associated with asthma, angina, ulcerative colitis, arrhythmia, heart failure, adrenal insufficiency and other conditions were banned.
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